Document Detail


Bioavailability of three formulations of intravenous diazepam.
MedLine Citation:
PMID:  3739596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been generally assumed that the bioavailability of different formulations of intravenous diazepam is identical. In a within-subject crossover study using eight healthy volunteers, we have found that both the initial and the overall plasma diazepam levels are significantly lower after both emulsion (Diazemuls) and micelle preparations than after an organic formulation (Valium). These findings are relevant to the interpretation of the results of past, present and future clinical studies involving intravenous diazepam. The studies with Valium and Diazemuls confirm the clinical impression of the lesser potency of the latter formulation.
Authors:
J P Fee; P S Collier; J W Dundee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  30     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Availability
Diazepam / administration & dosage,  blood*
Emulsions
Female
Humans
Injections, Intravenous
Kinetics
Male
Micelles
Middle Aged
Chemical
Reg. No./Substance:
0/Emulsions; 0/Micelles; 439-14-5/Diazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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