Document Detail


Bioavailability of residues: current status.
MedLine Citation:
PMID:  7003045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Bioavailability studies and current methodologies provide a very useful system for assessing the safety of radioactive drug related residues in food-producing animals. 2. Two year chronic toxicity studies provide useful information regarding the toxic properties of the parent drug but they have limited value for the assessment of safety for "second-pass" exposure of radioactive drug related residues of food-producing animals. The relevancy of the traditional two year toxicity study is seriously questioned as a method to determine the safety of drug related residues on the basis of a "second-pass" exposure. 3. More relevant toxicologic information can be gained by using the food-producing animal target species in toxicology studies. Comparative pharmacologic and toxicologic differences between laboratory animals and food-producing animals would be reduced.
Authors:
W G Huber; S R Becker; B P Archer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of environmental pathology and toxicology     Volume:  3     ISSN:  0146-4779     ISO Abbreviation:  J Environ Pathol Toxicol     Publication Date:    1980 Jun-Jul
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7801245     Medline TA:  J Environ Pathol Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability*
Digestive System / metabolism
Intestinal Absorption
Liver / metabolism
Meat*
Pesticide Residues / metabolism*
Pharmaceutical Preparations / metabolism*
Species Specificity
Chemical
Reg. No./Substance:
0/Pesticide Residues; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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