Document Detail


Bioavailability of phenylbutazone preparations in the horse.
MedLine Citation:
PMID:  7106088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma phenylbutazone concentrations were determined for up to 12 h in 6 horses following intravenous and oral phenylbutazone administration. To evaluate the bioavailability of different oral preparations, phenylbutazone was administered in a paste as well as the traditional powder form. The effect of the state of stomach contents on the absorption of phenylbutazone was investigated by administering the paste before and after feeding; the powder was given in a small bran mash and a full feed of lucerne chaff, wheaten chaff and bran. Despite great variability among individual horses both the paste form of phenylbutazone administered before a meal and the powder given in a small bran mash appeared to be almost completely absorbed, However, phenylbutazone paste administered after feeding or phenylbutazone powder given in a full feed resulted in lower peak plasma phenylbutazone levels than when administered on an empty or relatively empty stomach.
Authors:
R J Rose; J R Kohnke; J D Baggot
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  14     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  234-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animal Feed
Animals
Biological Availability
Female
Horses / metabolism*
Male
Phenylbutazone / administration & dosage,  blood,  metabolism*
Chemical
Reg. No./Substance:
50-33-9/Phenylbutazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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