Document Detail

Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection.
MedLine Citation:
PMID:  7815675     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients who have undergone ileal resection are at risk for developing magnesium depletion/deficiency because of poor absorption and decreased intake as well as increased endogenous losses. Magnesium repletion is difficult to accomplish because of the cathartic action of most oral magnesium supplements at therapeutic doses. The results of in vitro and in situ studies show that magnesium diglycinate (chelate) represents a highly available form of magnesium that is absorbed in part as an intact dipeptide in the proximal small intestine. METHODS: We conducted a double-blind, randomized crossover trial with 12 patients who had ileal resections in order to compare the bioavailability of a 100-mg dose of 26Mg-labeled chelate with MgO in this patient population. RESULTS: For the patient group as a whole, 26Mg absorption was low but was not different for the two supplements (23.5% vs 22.8% for magnesium chelate and MgO, respectively). However, 26Mg absorption was substantially greater from the chelate (23.5% vs 11.8%; p < .05) in the four patients who showed the greatest impairment of magnesium absorption with MgO and was better tolerated by all patients. Peak isotope enrichment also occurred significantly earlier after 26Mg chelate than after 26MgO ingestion (mean difference 3.2 +/- 1.3 hours; p < .05), and the area under the enrichment vs time curve was greater after chelate ingestion (p < .05). CONCLUSIONS: Data from this study support the suggestion that some portion of magnesium diglycinate is absorbed intact, probably via a dipeptide transport pathway. Magnesium diglycinate may be a good alternative to commonly used magnesium supplements in patients with intestinal resection.
S A Schuette; B A Lashner; M Janghorbani
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  18     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  430-5     Citation Subset:  IM    
Department of Medicine, University of Chicago, IL.
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MeSH Terms
Administration, Oral
Biological Availability
Crohn Disease / metabolism,  surgery
Cross-Over Studies
Double-Blind Method
Glycine / administration & dosage,  pharmacokinetics*
Ileum / surgery*
Intestinal Absorption
Magnesium / blood,  urine
Magnesium Oxide / administration & dosage,  pharmacokinetics*
Middle Aged
Organometallic Compounds / administration & dosage,  pharmacokinetics*
Grant Support
Reg. No./Substance:
0/Organometallic Compounds; 1309-48-4/Magnesium Oxide; 14783-68-7/magnesium diglycinate; 56-40-6/Glycine; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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