| Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport. | |
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MedLine Citation:
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PMID: 20487215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: As a natural antioxidant derived from dietary sources, lycopene has attracted considerable attention as a potent chemopreventative agent. Lycopene is an extremely lipophilic compound and absorption from dietary sources is estimated to be low and highly variable. As a result, plasma lycopene concentrations are poorly correlated with dietary intake of lycopene rich food stuffs. The development of an oral formulation remains a challenge that requires a better understanding of the mechanisms involved in the intestinal absorption of this compound. METHODS: The solubility of lycopene in simulated physiological fluids and bile salt mixed micelle formulations was determined. The extent of intestinal lymphatic transport and the absolute bioavailability of lycopene from a range of biorelevant media was evaluated in a mesenteric lymph duct cannulated anaesthetised rat model. RESULTS: The absolute bioavailability of lycopene after 8 h was 1.85 +/- 0.39%. The overall extent of the intestinal lymphatic transport was in the range of 0.6-3.4% of the administered dose. A strong positive correlation (r(2) > 0.9) between intestinal lycopene levels and intestinal triglyceride levels was demonstrated. CONCLUSIONS: The intestinal lymphatic route is the major uptake mechanism of lycopene from the gastrointestinal tract. Lycopene transport in intestinal lymph was closely associated with triglyceride transport in the lymph. Formulation strategies designed to promote intestinal lymphatic uptake, such as lipid-based formulations containing long-chain fatty acids (LCFA) or lecithin, may serve to enhance oral bioavailability of lycopene. |
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Authors:
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Waleed Faisal; Caitriona M O'Driscoll; Brendan T Griffin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 62 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-10 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 323-31 Citation Subset: IM |
Affiliation:
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School of Pharmacy, University College Cork, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Carotenoids / administration & dosage, isolation & purification, metabolism* Catheterization Dietary Fats / metabolism Emulsions / metabolism Fatty Acids / metabolism Intestinal Absorption Intestines / physiology* Kinetics Lymph / metabolism Lymphatic System / physiology* Lymphatic Vessels Male Rats Rats, Wistar Solubility Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Emulsions; 0/Fatty Acids; 0/Triglycerides; 36-88-4/Carotenoids; 502-65-8/lycopene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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