Document Detail

Bioavailability of iron bis-glycinate chelate in water.
MedLine Citation:
PMID:  11688077     Owner:  NLM     Status:  MEDLINE    
Iron amino acid chelate is being increasingly considered in programs for iron fortification of foods. The bioavailability of iron bis-glycinate chelate given in water was studied using a double-isotopic method in a group of 14 women. Iron absorption from aqueous solutions of 15 mg/L of elemental iron as either iron bis-glycine chelate or ferrous ascorbate was not significantly different (34.6% and 29.9% respectively). Standardized iron absorption of the iron bis-glycinate was 46.3% (standardized to 40% absorption of the reference dose). There was a significant correlations between (ln) iron absorption of iron bis-glycinate chelate with (ln) serum ferritin (r = -0.60, p < 0.03) and with (ln) iron absorption from ferrous ascorbate (r = 0.71, p < 0.006), suggesting that iron bis-glycinate chelate absorption is indeed regulated by the iron stores of the body.
M Olivares; F Pizarro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivos latinoamericanos de nutrición     Volume:  51     ISSN:  0004-0622     ISO Abbreviation:  Arch Latinoam Nutr     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-11-01     Completed Date:  2001-12-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0067507     Medline TA:  Arch Latinoam Nutr     Country:  Venezuela    
Other Details:
Languages:  eng     Pagination:  22-5     Citation Subset:  IM    
Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile.
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MeSH Terms
Antioxidants / pharmacokinetics
Ascorbic Acid / pharmacokinetics
Biological Availability
Ferritins / blood,  pharmacokinetics
Ferrous Compounds / blood,  pharmacokinetics*
Food, Fortified
Glycine / analogs & derivatives*,  blood,  pharmacokinetics*
Iron Chelating Agents / pharmacokinetics*
Iron Isotopes
Middle Aged
Reg. No./Substance:
0/Antioxidants; 0/Ferrous Compounds; 0/Iron Chelating Agents; 0/Iron Isotopes; 0/bis-glycino iron II; 50-81-7/Ascorbic Acid; 56-40-6/Glycine; 7732-18-5/Water; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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