Document Detail


Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women.
MedLine Citation:
PMID:  14585876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Obese women require higher gonadotrophin doses for ovarian stimulation and to trigger ovulation. The bioavailability of a drug is affected by its route of administration. Herein, the bioavailability of hCG was compared after intramuscular (i.m.) or subcutaneous (s.c.) injection in obese and non-obese women. METHODS: Twenty four Chinese women, 12 with a body mass index (BMI) >/==" BORDER="0">28 kg/m(2) and 12 with a BMI of 20-25 kg/m(2) were recruited as the obese and non-obese groups respectively. A single hCG injection was given intramuscularly on one occasion, and subcutaneously on a second occasion, separated by 4 weeks. Blood samples were taken at intervals for the pharmacokinetic study of hCG. RESULTS: Examination of the hCG plasma concentration-time curve showed the area under the curve (AUC) and maximum concentration (C(max)) of hCG to be significantly higher after i.m. injection than after s.c. injection in both the obese and non-obese groups. However, the AUC and C(max) values in obese women were significantly lower than in non-obese women, irrespective of whether i.m. or s.c. dosing was employed. CONCLUSIONS: Intramuscular dosing of hCG provided better bioavailability than s.c. dosing, but bioavailability was significantly less in obese women than in non-obese women.
Authors:
Carina C W Chan; Ernest H Y Ng; Maureen M Y Chan; Oi Shan Tang; Estella Y L Lau; William S B Yeung; Pak-Chung Ho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  18     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-30     Completed Date:  2004-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2294-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, SAR, China. cwcchan@graduate.hku.hk
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MeSH Terms
Descriptor/Qualifier:
Adult
Area Under Curve
Biological Availability
Body Mass Index
Case-Control Studies
Chorionic Gonadotropin / administration & dosage*,  blood,  pharmacokinetics*
Female
Humans
Injections, Intramuscular
Injections, Subcutaneous
Obesity / metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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