| Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women. | |
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MedLine Citation:
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PMID: 14585876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obese women require higher gonadotrophin doses for ovarian stimulation and to trigger ovulation. The bioavailability of a drug is affected by its route of administration. Herein, the bioavailability of hCG was compared after intramuscular (i.m.) or subcutaneous (s.c.) injection in obese and non-obese women. METHODS: Twenty four Chinese women, 12 with a body mass index (BMI) >/==" BORDER="0">28 kg/m(2) and 12 with a BMI of 20-25 kg/m(2) were recruited as the obese and non-obese groups respectively. A single hCG injection was given intramuscularly on one occasion, and subcutaneously on a second occasion, separated by 4 weeks. Blood samples were taken at intervals for the pharmacokinetic study of hCG. RESULTS: Examination of the hCG plasma concentration-time curve showed the area under the curve (AUC) and maximum concentration (C(max)) of hCG to be significantly higher after i.m. injection than after s.c. injection in both the obese and non-obese groups. However, the AUC and C(max) values in obese women were significantly lower than in non-obese women, irrespective of whether i.m. or s.c. dosing was employed. CONCLUSIONS: Intramuscular dosing of hCG provided better bioavailability than s.c. dosing, but bioavailability was significantly less in obese women than in non-obese women. |
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Authors:
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Carina C W Chan; Ernest H Y Ng; Maureen M Y Chan; Oi Shan Tang; Estella Y L Lau; William S B Yeung; Pak-Chung Ho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 18 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-30 Completed Date: 2004-06-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2294-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, SAR, China. cwcchan@graduate.hku.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Area Under Curve Biological Availability Body Mass Index Case-Control Studies Chorionic Gonadotropin / administration & dosage*, blood, pharmacokinetics* Female Humans Injections, Intramuscular Injections, Subcutaneous Obesity / metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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