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Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men.
MedLine Citation:
PMID:  22953831     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Glycitein is a Selective Estradiol Receptor Modulator (SERM) from soy. The study reports plasma bioavailability and urine excretion of glycitein compared to other soy isoflavones after a unique intake of food supplement based on soy germ containing 55.24mg isoflavones. Eighteen plasma and urinary sampling profiles collected over 48h from healthy young Caucasian men were analysed using specific ELISAs. Eight profiles contained equol. Glycitein T(max), C(max), AUC(0→24h) and T(½) in plasma were calculated. Urine T(max), % of excretion at 24h and clearance were assessed. Glycitein is one of the best absorbed flavonoids. Plasma steady-state level can be achieved by several intakes a day. Glycitein bioavailability is similar to that of daidzein and its urinary excretion is significantly higher than that of genistein. Equol does not affect glycitein bioavailability. Knowing glycitein bioavailability in man is essential for the development of soy-germ-based food supplements for health applications.
Authors:
Svitlana Shinkaruk; Marlène Durand; Valérie Lamothe; Allison Carpaye; Amandine Martinet; Philippe Chantre; Sébastien Vergne; Xavier Nogues; Nicholas Moore; Catherine Bennetau-Pelissero
Publication Detail:
Type:  Journal Article     Date:  2012-05-22
Journal Detail:
Title:  Food chemistry     Volume:  135     ISSN:  0308-8146     ISO Abbreviation:  Food Chem     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-09-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702639     Medline TA:  Food Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1104-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Univ. Bordeaux, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862, F-33000 Bordeaux, France; INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862, F-33000 Bordeaux, France.
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