Document Detail


Bioavailability of genistein and its glycoside genistin as measured in the portal vein of freely moving unanesthetized rats.
MedLine Citation:
PMID:  17032002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study describes an in vivo bioavailability experiment for genistein and its glycoside genistin, either as pure compounds or from a soy protein isolate extract, using freely moving unanesthetized rats with a cannulation in the portal vein. The results show that genistein is readily bioavailable, being observed in portal vein plasma at the first point of detection at 15 min after dosing. The AUC(0-24h) values for total genistein and its conjugates were 54, 24, and 13 microM h for genistein, genistin, and an enriched protein soy extract, respectively. These results indicate that the bioavailability of genistein is higher for the aglycon than for its glycoside. Genistin is partly absorbed in its glycosidic form. It is concluded that bioavailability studies based on portal vein plasma levels contribute to insight into the role of the intestine and liver in deglycosylation and uptake characteristics of glycosylated flavonoids.
Authors:
Aukje Steensma; Maria A W Faassen-Peters; Hub P J M Noteborn; Ivonne M C M Rietjens
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  54     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-11     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8006-12     Citation Subset:  IM    
Affiliation:
RIKILT--Institute for Food Safety, Bornsesteeg 45, 6700 AE Wageningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability
Diet
Feces / chemistry
Genistein / administration & dosage,  blood*,  pharmacokinetics*
Intestines / metabolism
Isoflavones / administration & dosage,  blood*,  pharmacokinetics*
Kinetics
Male
Portal Vein*
Rats
Rats, Wistar
Soybean Proteins / chemistry
Chemical
Reg. No./Substance:
0/Isoflavones; 0/Soybean Proteins; 446-72-0/Genistein; 529-59-9/genistin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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