| Bioavailability of genistein and its glycoside genistin as measured in the portal vein of freely moving unanesthetized rats. | |
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MedLine Citation:
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PMID: 17032002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study describes an in vivo bioavailability experiment for genistein and its glycoside genistin, either as pure compounds or from a soy protein isolate extract, using freely moving unanesthetized rats with a cannulation in the portal vein. The results show that genistein is readily bioavailable, being observed in portal vein plasma at the first point of detection at 15 min after dosing. The AUC(0-24h) values for total genistein and its conjugates were 54, 24, and 13 microM h for genistein, genistin, and an enriched protein soy extract, respectively. These results indicate that the bioavailability of genistein is higher for the aglycon than for its glycoside. Genistin is partly absorbed in its glycosidic form. It is concluded that bioavailability studies based on portal vein plasma levels contribute to insight into the role of the intestine and liver in deglycosylation and uptake characteristics of glycosylated flavonoids. |
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Authors:
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Aukje Steensma; Maria A W Faassen-Peters; Hub P J M Noteborn; Ivonne M C M Rietjens |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 54 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-11 Completed Date: 2006-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 8006-12 Citation Subset: IM |
Affiliation:
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RIKILT--Institute for Food Safety, Bornsesteeg 45, 6700 AE Wageningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Availability Diet Feces / chemistry Genistein / administration & dosage, blood*, pharmacokinetics* Intestines / metabolism Isoflavones / administration & dosage, blood*, pharmacokinetics* Kinetics Male Portal Vein* Rats Rats, Wistar Soybean Proteins / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Soybean Proteins; 446-72-0/Genistein; 529-59-9/genistin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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