Document Detail


Bioavailability of folates in selected foods incorporated into amino acid-based diets fed to rats.
MedLine Citation:
PMID:  2262810     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two experiments were conducted to determine the feasibility of using a folate depletion/repletion protocol with rats fed an amino acid-based diet to measure the bioavailability of food folate. Growth, liver folate and serum folate of depleted rats that were fed test foods incorporated into a folate-free, amino acid-based diet were standardized against similar responses of rats fed known amounts of folic acid incorporated into the same diet. Bioavailability of folate of cooked broccoli, refried beans and orange juice concentrate in experiment 1 was 80-89, 113 and 62%, respectively, based on growth response; in experiment 2, values for cooked and raw broccoli, cooked cabbage and cantaloupe were 95, 103, 74 and 81%, respectively. The results demonstrate that in addition to serum and liver folate concentrations, growth may be a useful response criterion to evaluate the bioavailability of folates in foods. Further research is needed to determine the relevance of these bioavailability estimates to human nutrition.
Authors:
A J Clifford; A D Jones; N D Bills
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  120     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-02-07     Completed Date:  1991-02-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1640-7     Citation Subset:  IM    
Affiliation:
Department of Nutrition, University of California, Davis 95616-3376.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / administration & dosage*
Animals
Biological Availability
Brassica
Citrus
Diet*
Fabaceae
Folic Acid / administration & dosage,  blood,  pharmacokinetics*
Fruit
Liver / metabolism
Male
Plants, Medicinal
Rats
Rats, Inbred Strains
Vegetables
Weight Gain
Grant Support
ID/Acronym/Agency:
AM-16726/AM/NIADDK NIH HHS; DK-38637/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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