| Bioavailability of the flavanone naringenin and its glycosides in rats. | |
| | |
MedLine Citation:
|
PMID: 11093936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Naringenin, the predominant flavanone in grapefruit, mainly occurs as glycosides such as naringenin-7- rhamnoglucoside or naringenin-7-glucoside. This study compared kinetics of absorption of naringenin and its glycosides in rats either after a single flavanone-containing meal or after adaptation to a diet for 14 days. Regardless of the diet, circulating metabolites were glucurono- and sulfoconjugated derivatives of naringenin. The kinetics of absorption of naringenin and naringenin-7-glucoside were similar, whereas naringenin-7-rhamnoglucoside exhibited a delay in its intestinal absorption, resulting in decreased bioavailability. After naringenin-7-glucoside feeding, no glucoside was found in the cecum. However, after feeding naringenin-7-rhamnoglucoside, some naringenin-7-rhamnoglucoside accumulated in cecum before being hydrolyzed by intestinal microflora. Adaptation to flavanone diets did not induce accumulation of plasma naringenin. Moreover, flavanone cecal content markedly decreased after adaptation, and almost no naringenin-7-rhamnoglucoside was recovered after naringenin-7-rhamnoglucoside feeding, suggesting that an adaptation of cecal microflora had occurred. Overall, these data indicate that flavanones are efficiently absorbed after feeding to rats and that their bioavailability is related to their glycosidic moiety. |
| | |
Authors:
|
C Felgines; O Texier; C Morand; C Manach; A Scalbert; F Régerat; C Rémésy |
Related Documents
:
|
21572846 - Comparability of weighed dietary records and a self-administered diet history questionn... 21534836 - Environmental changes to control obesity: a randomized controlled trial in manufacturin... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 279 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2000 Dec |
Date Detail:
|
Created Date: 2001-01-02 Completed Date: 2001-01-02 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G1148-54 Citation Subset: IM |
Affiliation:
|
Laboratoire de Pharmacognosie, Faculté de Pharmacie, 63001 Clermont-Ferrand, France. FELGINES@u-clermont1.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Adaptation, Physiological Animals Biological Availability Chromatography, High Pressure Liquid Flavanones* Flavonoids / chemistry, pharmacokinetics* Food Glucosides / pharmacokinetics Male Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Flavanones; 0/Flavonoids; 0/Glucosides; 480-41-1/naringenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers.
Next Document: Whole cell current and membrane potential regulation by a human smooth muscle mechanosensitive calci...