| Bioavailability and elimination of digitoxin in patients with hepatorenal insufficiency. | |
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MedLine Citation:
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PMID: 3946177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following administration of digitoxin, 1 mg intravenously, the pharmacokinetics of this glycoside were studied in eight healthy volunteers and in eight patients with hepatorenal insufficiency (mean creatinine clearance 19.6 +/- 2.9 ml/min; antipyrine clearance 25.6 +/- 3.2 ml/min; means +/- SEM). Liver cirrhosis of the patients was confirmed by liver biopsy. Plasma protein binding of digitoxin (means +/- SEM) was 95.1 +/- 0.7% in the patients and 95.6 +/- 1.2% in the volunteers (NS). Total body clearance of digitoxin was 0.0530 +/- 0.0040 ml/min/kg of body weight in the patients and 0.0547 +/- 0.0043 ml/min/kg of body weight in the healthy subjects (NS). When elimination half-lives of the patients and the volunteers were compared, there was also no significant difference (7.0 +/- 0.77 days in the patient group and 7.8 +/- 0.8 days in the volunteers). Our data concerning digitoxin kinetics in patients with hepatorenal insufficiency do not indicate an accumulation of the drug in these patients. |
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Authors:
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W Kirch; E E Ohnhaus; P Dylewicz; J Pabst; L Storstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 111 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-10 Completed Date: 1986-03-10 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 325-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Availability Body Weight Digitoxin / blood, metabolism*, urine Female Half-Life Humans Kidney Diseases / metabolism* Kinetics Liver Diseases / metabolism* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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71-63-6/Digitoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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