Document Detail


Bioavailability and dissolution behavior of trisulfapyrimidine suspensions.
MedLine Citation:
PMID:  458566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bioavailability of seven commercial trisulfapyrimidine suspensions was studied in 14 adult male volunteers. Fifteen blood samples were collected over a 48-hr period following administration of a 1-g dose of each suspension. Serum was assayed for each component (sulfadiazine, sulfamerazine, and sulfamethazine) by high-pressure liquid chromatography. Analysis of variance indicated several significant differences among the seven commercial preparations with respect to Cmax Tmax, and AUC for sulfadiazine, sulfamerazine, and sulfamethazine, The in vitro behavior of each suspension was then studied by the paddle method of the Food and Drug Administration. A 0.5-ml sample was introduced into 900 ml of hydrochloric acid (2.2 x 10(-4) M) at 37 degree and dissolved using a paddle speed of 25 rpm. Samples withdrawn at 15 and 30 min were analyzed by high-pressure liquid chromatography, and the percent of sulfadiazine, sulfamerazine, and sulfamethazine was calculated. Significant correlation was obtained between an in vivo parameter (Cmax for sulfadiazine) and an in vitro parameter (percent sulfadiazine dissolved in 30 min). Results indicate that this method is suitable for the in vitro screening of trisulapyrimidine suspensions.
Authors:
L K Mathur; J M Jaffe; R I Poust; H Barry; T J Goehl; V P Shah; J L Colaizzi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  68     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  699-702     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Availability
Humans
Male
Solubility
Sulfadiazine / administration & dosage,  blood*
Sulfamerazine / administration & dosage,  blood*
Sulfamethazine / administration & dosage,  blood*
Sulfonamides / administration & dosage,  metabolism*
Suspensions
Chemical
Reg. No./Substance:
0/Sulfonamides; 0/Suspensions; 127-79-7/Sulfamerazine; 57-68-1/Sulfamethazine; 68-35-9/Sulfadiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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