Document Detail


Bioavailability, disposition kinetics and renal clearance of ampicillin following three routes of administration in sheep.
MedLine Citation:
PMID:  2501955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bioavailability, disposition kinetics and renal clearance of ampicillin were investigated in 8 sheep following intravenous (i.v.), or intramuscular (i.m.) injection of 10 mg/kg or oral administration of 20 mg/kg dose. Peak of absorption was achieved in 26 +/- 9 min (mean +/- SD) after i.m. and 85 +/- 24 min after oral administration. The relative bioavailability of i.m. injected drug was 95 +/- 20 per cent compared to only 37 +/- 7 per cent following oral administration of double the dose. The disposition kinetics parameters of ampicillin were comparable in sheep with all three routes of drug administration. The renal clearance of ampicillin varied between 0.20 and 0.62 ml/min.kg while total body clearance was 50 to 64 ml/min.kg. The fractional urinary excretion of ampicillin in the first 8 hours after dosing was less than 1 per cent of the dose by all three routes.
Authors:
M Nawaz; M Hafeez; F H Khan; R Nawaz; T Iqbal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Veterinärmedizin. Reihe A     Volume:  36     ISSN:  0514-7158     ISO Abbreviation:  Zentralbl Veterinarmed A     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331323     Medline TA:  Zentralbl Veterinarmed A     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral / veterinary
Ampicillin / administration & dosage,  pharmacokinetics*
Animals
Biological Availability
Female
Injections, Intramuscular / veterinary
Injections, Intravenous / veterinary
Kidney / metabolism
Sheep / metabolism*
Chemical
Reg. No./Substance:
69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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