Document Detail


Bioavailability of digoxin tablets in patients with gastrointestinal dysfunction.
MedLine Citation:
PMID:  7386507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 47 patients with disorders of the gastrointestinal tract, the bioavailability of digoxin tablets was assessed by measuring the area under the serum concentration-time curve (AUC) after the oral administration of single 0.5 mg doses. In 13 or 14 patients who had undergone a previous ileal resection, in 10 of 10 patients with sprue and in 14 of 14 patients with a variety of disorders of the gastrointestinal tract, digoxin absorption was normal despite marked steatorrhea in many. A patient with extensive jejunal and ileal resection, and inflammation of the remaining small bowel,was the sole exception. Impaired digoxin bioavailability was found in five of nine patients who had undergone jejunoileal bypass procedures (bypass patients. A strong correlation was noted between the length of jejunum remaining in continuity and the AUC (r = 0.86, p less than 0.01). Two of three bypass patients also showed decreased absorption of more rapidly dissolving tablets or an elixir. Digoxin bioavailability correlated significantly with and 2 hour serum xylose levels but not with urinary xylose excretion, fecal fat or the Schilling test result. The findings are consistent with the role of the upper small bowel as the predominant site of digoxin absorption as well as the reserve function of the ileum in the event of jejunal dysfunction or bypass.
Authors:
C D Gerson; E H Lowe; J Lindenbaum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  69     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Availability
Celiac Disease / metabolism
Digoxin / metabolism*
Female
Gastrointestinal Diseases / metabolism*
Humans
Ileum / physiology
Intestinal Absorption
Jejunum / physiology
Male
Middle Aged
Postgastrectomy Syndromes / metabolism
Xylose / metabolism
Chemical
Reg. No./Substance:
0/Xylose; 20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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