Document Detail

Bioavailability of different brands of tetracycline in undernourished subjects.
MedLine Citation:
PMID:  1551739     Owner:  NLM     Status:  MEDLINE    
Chemical estimation of seven different marketed brands of tetracycline/Hcl capsules for tetracycline content showed six brands were not meeting the Indian pharmacopia 1985 prescribed standards. However, their dissolution rate and disintegration time were in accordance with United States pharmacopia 1985 specifications. One standard and one substandard brand of tetracycline were selected and their bioavailability, after single dose and plasma steady-state levels after multiple dosing in well nourished and undernourished subjects were determined. The bioavailability of substandard product as determined from 48 h urinary tetracycline excretion was significantly lower as compared to standard product both in well-nourished and undernourished subjects. The plasma steady-state concentrations with the substandard product were below the generally recommended minimum inhibitory concentrations, more so in undernourished subjects. These results indicate that the use of sub-standard tetracycline products in undernourished subjects may lead to therapeutic failures and/or result in the development of resistant microorganisms.
K K Santosh; T C Raghuram; K Krishnaswamy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  30     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  IM    
National Institute of Nutrition, Hyderabad, India.
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MeSH Terms
Biological Availability
Chemistry, Pharmaceutical
Middle Aged
Nutrition Disorders / metabolism*
Tetracycline / pharmacokinetics*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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