Document Detail


Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy.
MedLine Citation:
PMID:  20226754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intestinal absorption and metabolism of 385 micromol chlorogenic acids following a single intake of 200 mL of instant coffee by human volunteers with an ileostomy was investigated. HPLC-MS(3) analysis of 0-24h post-ingestion ileal effluent revealed the presence of 274+/-28 micromol of chlorogenic acids and their metabolites accounting for 71+/-7% of intake. Of the compounds recovered, 78% comprised parent compounds initially present in the coffee, and 22% were metabolites including free and sulfated caffeic and ferulic acids. Over a 24h period after ingestion of the coffee, excretion of chlorogenic acid metabolites in urine accounted for 8+/-1% of intake, the main compounds being ferulic acid-4-O-sulfate, caffeic acid-3-O-sulfate, isoferulic acid-3-O-glucuronide and dihydrocaffeic acid-3-O-sulfate. In contrast, after drinking a similar coffee, urinary excretion by humans with an intact colon corresponded to 29+/-4% of chlorogenic acid intake. This difference was due to the excretion of higher levels of dihydroferulic acid and feruloylglycine together with sulfate and glucuronide conjugates of dihydrocaffeic and dihydroferulic acids. This highlights the importance of colonic metabolism. Comparison of the data obtained in the current study with that of Stalmach et al. facilitated elucidation of the pathways involved in post-ingestion metabolism of chlorogenic acids and also helped distinguish between compounds absorbed in the small and the large intestine.
Authors:
Angélique Stalmach; Heike Steiling; Gary Williamson; Alan Crozier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-11
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  501     ISSN:  1096-0384     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  98-105     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Plant Products and Human Nutrition Group, Graham Kerr Building, Faculty of Medicine, University of Glasgow, Glasgow G128QQ, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Availability
Caffeic Acids / chemistry,  pharmacokinetics,  urine
Chlorogenic Acid / chemistry,  pharmacokinetics*,  urine
Chromatography, High Pressure Liquid
Coffee / chemistry*
Coumaric Acids / chemistry,  pharmacokinetics,  urine
Female
Humans
Ileostomy*
Ileum / metabolism
Intestinal Absorption
Male
Middle Aged
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
0/Caffeic Acids; 0/Coffee; 0/Coumaric Acids; 1135-24-6/ferulic acid; 327-97-9/Chlorogenic Acid

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