Document Detail

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.
MedLine Citation:
PMID:  15640486     Owner:  NLM     Status:  MEDLINE    
Polyphenols are abundant micronutrients in our diet, and evidence for their role in the prevention of degenerative diseases is emerging. Bioavailability differs greatly from one polyphenol to another, so that the most abundant polyphenols in our diet are not necessarily those leading to the highest concentrations of active metabolites in target tissues. Mean values for the maximal plasma concentration, the time to reach the maximal plasma concentration, the area under the plasma concentration-time curve, the elimination half-life, and the relative urinary excretion were calculated for 18 major polyphenols. We used data from 97 studies that investigated the kinetics and extent of polyphenol absorption among adults, after ingestion of a single dose of polyphenol provided as pure compound, plant extract, or whole food/beverage. The metabolites present in blood, resulting from digestive and hepatic activity, usually differ from the native compounds. The nature of the known metabolites is described when data are available. The plasma concentrations of total metabolites ranged from 0 to 4 mumol/L with an intake of 50 mg aglycone equivalents, and the relative urinary excretion ranged from 0.3% to 43% of the ingested dose, depending on the polyphenol. Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics. The least well-absorbed polyphenols are the proanthocyanidins, the galloylated tea catechins, and the anthocyanins. Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols.
Claudine Manach; Gary Williamson; Christine Morand; Augustin Scalbert; Christian Rémésy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  81     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-10     Completed Date:  2005-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230S-242S     Citation Subset:  AIM; IM    
Unité des Maladies Métaboliques et Micronutriments, INRA, Saint-Genès Champanelle, France.
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MeSH Terms
Anthocyanins / blood,  pharmacokinetics*,  urine
Area Under Curve
Biological Availability
Flavonoids / metabolism,  pharmacokinetics*,  therapeutic use
Food Analysis
Intestinal Absorption
Isoflavones / blood,  pharmacokinetics*,  urine
Phenols / metabolism,  pharmacokinetics*,  therapeutic use
Reg. No./Substance:
0/Anthocyanins; 0/Flavonoids; 0/Isoflavones; 0/Phenols; 0/polyphenols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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