Document Detail

Bioavailability, Distribution and Anti-oxidative Effects of Selected Triterpenes in Mice.
MedLine Citation:
PMID:  22816768     Owner:  NLM     Status:  Publisher    
This study analyzed the content of eight triterpenes (oleanolic acid, ursolic acid, arjunolic acid, asiatic acid, boswellic acid, corosolic acid, madecassic acid and maslinic acid) in ten vegetables and eight fruits. These compounds at 0.5% were supplied to mice for 4 or 8 weeks. The bioavailability, tissue distribution and anti-oxidative protection of these triterpenes were examined. Results showed that triterpenes could be detected in eight vegetables and six fruits. Basil and brown mustard contained 7 test triterpenes, in the range of 14-102 mg/100 g dry weight. The level of each triterpene in plasma, brain, heart, liver, kidney, colon and bladder increased with increasing feeding period from 4 weeks to 8 weeks (P<0.05). Renal homogenates from mice with triterpenes intake had greater anti-oxidative effects against glucose induced glutathione loss, malondialdehyde and oxidized glutathione production when compared with those from control groups (P<0.05). These data support that these triterpenes could be absorbed and deposited in their intact forms, which in turn exerted in vivo anti-oxidative protection.
Mei-Chin Yin; Ming-Cheng Lin; Mei-Chin Mong; Chia-Yu Lin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-20
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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