Document Detail

Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans.
MedLine Citation:
PMID:  10801919     Owner:  NLM     Status:  MEDLINE    
The flavonoid quercetin is an antioxidant which occurs in foods mainly as glycosides. The sugar moiety in quercetin glycosides affects their bioavailability in humans. Quercetin-3-rutinoside is an important form of quercetin in foods, but its bioavailability in humans is only 20% of that of quercetin-4'-glucoside. Quercetin-3-rutinoside can be transformed into quercetin-3-glucoside by splitting off a rhamnose molecule. We studied whether this 3-glucoside has the same high bioavailability as the quercetin-4'-glucoside. To that end we fed five healthy men and four healthy women (19-57 y) a single dose of 325 micromol of pure quercetin-3-glucoside and a single dose of 331 micromol of pure quercetin-4'-glucoside and followed the plasma quercetin concentrations. The bioavailability was the same for both quercetin glucosides. The mean peak plasma concentration of quercetin was 5.0+/-1.0 micromol/L (+/-SE) after subjects had ingested quercetin-3-glucoside and 4.5+/-0.7 micromol/L after quercetin-4'-glucoside consumption. Peak concentration was reached 37 +/-12 min after ingestion of quercetin-3-glucoside and 27+/-5 min after quercetin-4'-glucoside. Half-life of elimination of quercetin from blood was 18.5+/-0.8 h after ingestion of quercetin-3-glucoside and 17.7+/-0.9 h after quercetin-4'-glucoside. We conclude that quercetin glucosides are rapidly absorbed in humans, irrespective of the position of the glucose moiety. Conversion of quercetin glycosides into glucosides is a promising strategy to enhance bioavailability of quercetin from foods.
M R Olthof; P C Hollman; T B Vree; M B Katan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  130     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-07     Completed Date:  2000-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1200-3     Citation Subset:  IM    
Division of Human Nutrition and Epidemiology, Wageningen University and Research Centre, 6700 EV, Wageningen, The Netherlands.
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MeSH Terms
Administration, Oral
Area Under Curve
Chromatography, High Pressure Liquid
Middle Aged
Parasympatholytics / chemistry,  metabolism,  pharmacokinetics*
Plant Extracts / chemistry,  metabolism,  pharmacokinetics
Quercetin / analogs & derivatives*,  chemistry,  metabolism,  pharmacokinetics
Structure-Activity Relationship
Reg. No./Substance:
0/Parasympatholytics; 0/Plant Extracts; 117-39-5/Quercetin; 20229-56-5/spiraeoside; 21637-25-2/isoquercitrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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