Document Detail

Bioassayable growth hormone release in rats in response to a single bout of treadmill exercise.
MedLine Citation:
PMID:  11090564     Owner:  NLM     Status:  MEDLINE    
Plasma growth hormone (GH) measured by immunoassay [immunoassayable GH (IGH)] and by tibial bioassay [bioassayable GH (BGH)] increases in humans in response to exercise. In rats, however, IGH does not change in response to exercise. The objective of this study was to determine the BGH response to an acute exercise bout in rats. The rats ran on a treadmill at a rate of 27 m/min for 15 min, after which plasma and pituitary hormones, including IGH and BGH, and plasma metabolites were measured. Plasma and pituitary IGH were unchanged from control groups after the acute exercise bout, whereas plasma BGH was increased by 300% and pituitary BGH was decreased by 50%. Plasma thyroxine and corticosterone levels were significantly increased after a single exercise bout, but plasma testosterone, 3,5, 3'-triiodothyronine, glucose, lactate, and triglyceride concentrations were unchanged. Given previous results from in situ nerve stimulation studies (Gosselink KL, Grindeland RE, Roy RR, Zhong H, Bigbee AJ, Grossman EJ, and Edgerton VR. J Appl Physiol 84: 1425-1430, 1998), these in vivo results are consistent with the rapid BGH response during exercise being induced by the activation of muscle afferents.
A J Bigbee; K L Gosselink; R R Roy; R E Grindeland; V R Edgerton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  89     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-26     Completed Date:  2001-01-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2174-8     Citation Subset:  IM; S    
Department of Neurobiology, University of California, Los Angeles 90095, California.
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MeSH Terms
Biological Assay
Corticosterone / blood
Growth Hormone / blood,  metabolism*
Motor Activity / physiology*
Pituitary Gland / metabolism
Rats, Sprague-Dawley
Thyroxine / blood
Reg. No./Substance:
50-22-6/Corticosterone; 7488-70-2/Thyroxine; 9002-72-6/Growth Hormone
K L Gosselink / U CA, Los Angeles; V R Edgerton / U CA, Los Angeles

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