Document Detail

Bioassayable growth hormone release in rats in response to a single bout of treadmill exercise.
MedLine Citation:
PMID:  11090564     Owner:  NLM     Status:  MEDLINE    
Plasma growth hormone (GH) measured by immunoassay [immunoassayable GH (IGH)] and by tibial bioassay [bioassayable GH (BGH)] increases in humans in response to exercise. In rats, however, IGH does not change in response to exercise. The objective of this study was to determine the BGH response to an acute exercise bout in rats. The rats ran on a treadmill at a rate of 27 m/min for 15 min, after which plasma and pituitary hormones, including IGH and BGH, and plasma metabolites were measured. Plasma and pituitary IGH were unchanged from control groups after the acute exercise bout, whereas plasma BGH was increased by 300% and pituitary BGH was decreased by 50%. Plasma thyroxine and corticosterone levels were significantly increased after a single exercise bout, but plasma testosterone, 3,5, 3'-triiodothyronine, glucose, lactate, and triglyceride concentrations were unchanged. Given previous results from in situ nerve stimulation studies (Gosselink KL, Grindeland RE, Roy RR, Zhong H, Bigbee AJ, Grossman EJ, and Edgerton VR. J Appl Physiol 84: 1425-1430, 1998), these in vivo results are consistent with the rapid BGH response during exercise being induced by the activation of muscle afferents.
A J Bigbee; K L Gosselink; R R Roy; R E Grindeland; V R Edgerton
Related Documents :
14504954 - Acute hormonal responses of a high impact physical exercise session in early postmenopa...
21357374 - Exercise duration as a determinant of vascular function and antioxidant balance in pati...
23042474 - Research to encourage exercise for fibromyalgia (reef): use of motivational interviewin...
16095404 - Acute hormonal responses to submaximal and maximal heavy resistance and explosive exerc...
17145114 - Cardiac troponin increases among runners in the boston marathon.
8824694 - The effect of acute vs chronic treatment with beta-adrenoceptor blockade on exercise pe...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  89     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-26     Completed Date:  2001-01-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2174-8     Citation Subset:  IM; S    
Department of Neurobiology, University of California, Los Angeles 90095, California.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Assay
Corticosterone / blood
Growth Hormone / blood,  metabolism*
Motor Activity / physiology*
Pituitary Gland / metabolism
Rats, Sprague-Dawley
Thyroxine / blood
Reg. No./Substance:
50-22-6/Corticosterone; 7488-70-2/Thyroxine; 9002-72-6/Growth Hormone
K L Gosselink / U CA, Los Angeles; V R Edgerton / U CA, Los Angeles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Macromolecule transfer through mesothelium and connective tissue.
Next Document:  Ventilatory response to incremental and constant-workload exercise in the presence of a thoracic res...