| Bioassay of Reserpine for Possible Carcinogenicity (CAS No. 50-55-5). | |
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MedLine Citation:
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PMID: 12778186 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A bioassay for possible carcinogenicity of reserpine, an antihypertensive drug for human use, was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were administered reserpine at two doses, 5 ppm and 10 ppm, for 103 weeks and then observed for an additional 2 weeks. Matched controls consisted of groups of 50 untreated rats and 50 untreated mice of each sex. All surviving animals were killed and necropsied at the end of 104 or 105 weeks. The significant effects that could be related to administration of reserpine at the doses used were decreased body weight and increased tumor formation in dosed male rats and in mice of both sexes. Dosed male rats had an increased incidence of adrenal medullary pheochromocytomas. Among dosed mice, some males developed undifferentiatedcarcinomas of the seminal vesicles, which rarely occur in control mice, and females had an increased incidence of mammary cancer. It was concluded that, under the conditions of the bioassay, reserpine was carcinogenic in male rats and in mice of both sexes, producing three different kinds of cancers. reserpine was not carcinogenic for female rats, but they may not have received a high enough dose for maximum test sensitivity. Levels of Evidence of Carcinogenicity: Male Rats: Positive Female Rats: Negative Male Mice: Positive Female Mice: Positive |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: National Toxicology Program technical report series Volume: 193 ISSN: 0888-8051 ISO Abbreviation: Natl Toxicol Program Tech Rep Ser Publication Date: 1982 Nov |
Date Detail:
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Created Date: 2003-Jun-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500747 Medline TA: Natl Toxicol Program Tech Rep Ser Country: - |
Other Details:
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Languages: ENG Pagination: 1-123 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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