Document Detail


Bioartificial kidney. II. A convective flow model of a hollow fiber bioartificial renal tubule.
MedLine Citation:
PMID:  10712731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An existing model for volume transport in the rat proximal tubule was modified and applied to a bioartificial renal tubule. The predicted volume transport agrees well with experimental data. The volume transport model was coupled to the analytic solutions of flow in the bioartificial renal tubule bioreactor, operated in the open-shell mode with perfusion in both the lumen and surrounding shell. The results suggest that the performance of a multifiber bioreactor can be improved by controlling shell inlet conditions and fiber spacing. These results have important implications for the design and analysis not only for the bioartificial renal tubule bioreactor but also for the general case of hollow fiber bioreactors operated in the open-shell mode with perfusion in both the lumen and surrounding shell.
Authors:
Y Moussy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biotechnology and bioengineering     Volume:  68     ISSN:  0006-3592     ISO Abbreviation:  Biotechnol. Bioeng.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-20     Completed Date:  2000-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7502021     Medline TA:  Biotechnol Bioeng     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
Affiliation:
Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA. moussy@titan.me.jhu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Kidney Tubules*
Kidney, Artificial*
Models, Theoretical*
Rats
Rheology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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