Document Detail


Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria.
MedLine Citation:
PMID:  21031625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antiproliferative effects of n-hexane, chloroform and aqueous methanol extracts prepared from the whole plant of Centaurea arenaria M.B. ex Willd. were investigated against cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF7) and skin epidermoid carcinoma (A431) cells, using the MTT assay. The chloroform extract displayed high tumour cell proliferation inhibitory activity (higher than 85% at 10 μg/mL concentration), and was therefore subjected to a bioassay-guided multistep separation procedure. Flavonoids (eupatilin, eupatorin, 3'-methyleupatorin, apigenin and isokaempferid), lignans (arctigenin, arctiin and matairesinol), the sesquiterpene cnicin, serotonin conjugates (moschamine and cis-moschamine), β-amyrin and β-sitosterin-β-D-glycopyranoside, identified by means of UV, MS and NMR spectroscopy, were obtained for the first time from this species. The isolated compounds were also evaluated for their tumour cell growth inhibitory activities on HeLa, MCF7 and A431 cells, and different types of secondary metabolites were found to be responsible for the antitumour effects of the extracts; in addition to moderately active compounds (isokaempferid and moschamine), especially apigenin, eupatorin, arctigenin, arctiin, matairesinol and cnicin exert marked antitumour effects against these cell lines.
Authors:
Bence Csapi; Zsuzsanna Hajdú; István Zupkó; Agnes Berényi; Peter Forgo; Pál Szabó; Judit Hohmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1664-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / isolation & purification,  pharmacology*
Centaurea / chemistry*
Flavonoids / isolation & purification,  pharmacology
Hela Cells
Humans
Plant Extracts / pharmacology*
Sesquiterpenes / isolation & purification,  pharmacology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Flavonoids; 0/Plant Extracts; 0/Sesquiterpenes

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