| Bioactivity of α-Lactalbumin Related to its Interaction with Fatty Acids: A Review. | |
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MedLine Citation:
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PMID: 21838558 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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α-Lactalbumin (α-LA) is a whey protein that has been extensively studied for its folding properties and its ability to bind several cations. An interesting property of α-LA is its ability to interact with fatty acids, although this interaction requires the previous unfolding of the protein by removing the Ca(2+) bound. The main function of α-LA is to participate in lactose biosynthesis. However, other biological functions have been attributed to the protein in the last decade. It has been reported that a particular form of human and bovine apo-α-LA induces apoptosis in tumoral and immature cells though spares healthy differentiated cells. The conversion of α-LA to the active apoptotic form requires the unfolding of the protein and the binding of specific fatty acids, mainly unsaturated C18 fatty acids in the cis-conformation. Likewise, it has been shown that a folding variant of α-LA and also some peptidic fragments have a bactericidal activity. The proposed functions for α-LA open new perspectives for its use as a potential ingredient to be added in functional foods or in nutraceutical products. This review summarizes the current state of knowledge on the subject of the interaction of α-LA with fatty acids, and the consequences of this interaction on its bioactivity. |
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Authors:
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Chockry Barbana; Lourdes Sánchez; María D Pérez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical reviews in food science and nutrition Volume: 51 ISSN: 1549-7852 ISO Abbreviation: Crit Rev Food Sci Nutr Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8914818 Medline TA: Crit Rev Food Sci Nutr Country: England |
Other Details:
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Languages: eng Pagination: 783-94 Citation Subset: IM |
Affiliation:
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a Bioquímica y Tecnología de los Alimentos, Facultad Veterinaria , Universidad de Zaragoza , C/Miguel Servet 177, 50013 , Zaragoza , Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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