| Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. | |
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MedLine Citation:
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PMID: 20806783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inhibition of protein tyrosine phosphatase 1B (PTP1B) is of substantial interest for the treatment of type-2 diabetes mellitus. Using an in vitro enzyme assay with human recombinant PTP1B 1,2,3,4,6-penta-O-galloyl-D-glucopyranose was isolated from the roots of Paeonia lactiflora as an inhibitor of PTP1B, with an IC(50) value of 4.8 μM. Additionally, 1 was shown to act as an insulin sensitizer in human hepatoma cells (HCC-1.2) at a concentration of 10 μM. Thus, a potential new mechanism of action is provided explaining the antidiabetic properties of P. lactiflora. |
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Authors:
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Renate R Baumgartner; Dirk Steinmann; Elke H Heiss; Atanas G Atanasov; Markus Ganzera; Hermann Stuppner; Verena M Dirsch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 73 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1578-81 Citation Subset: IM |
Affiliation:
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Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Austria Carcinoma, Hepatocellular / metabolism Diabetes Mellitus, Type 2 / drug therapy Enzyme Assays Humans Hydrolyzable Tannins / chemistry, isolation & purification*, pharmacology* Hypoglycemic Agents / chemistry, isolation & purification*, pharmacology* Insulin / metabolism Paeonia / chemistry* Plant Roots / chemistry Plants, Medicinal / chemistry* Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Hydrolyzable Tannins; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 14937-32-7/beta-penta-O-galloyl-glucose; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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