| Bioactive substance from Grifola frondosa (maitake) mushroom inhibits CCAAT enhancer binding protein beta and delta expression on C3H10T1/2 B2C1 adipocyte cells. | |
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MedLine Citation:
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PMID: 18635913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B(2)C(1) preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or beta-catenin, which inhibit the expression of Glut4, PPARgamma and C/EBPalpha. The compound reduced the expression time of C/EBPbeta and C/EBPdelta. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARgamma or C/EBPalpha because of the reduced expression time of C/EBPbeta and C/EBPdelta. |
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Authors:
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Katsuhiko Minamino; Yuri Yanaga; Masaru Ohtsuru |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 54 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-18 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 250-4 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University, Nishinomiya, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism* Animals Blotting, Western CCAAT-Enhancer-Binding Protein-beta / drug effects*, genetics, metabolism CCAAT-Enhancer-Binding Protein-delta / drug effects*, genetics, metabolism Cell Culture Techniques Cell Differentiation / genetics Electrophoresis, Polyacrylamide Gel Gene Expression Regulation / genetics Grifola* / chemistry Mice Plant Extracts / isolation & purification, pharmacology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/CCAAT-Enhancer-Binding Protein-beta; 0/Plant Extracts; 142662-43-9/CCAAT-Enhancer-Binding Protein-delta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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