Document Detail

Bioactive substance from Grifola frondosa (maitake) mushroom inhibits CCAAT enhancer binding protein beta and delta expression on C3H10T1/2 B2C1 adipocyte cells.
MedLine Citation:
PMID:  18635913     Owner:  NLM     Status:  MEDLINE    
Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B(2)C(1) preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or beta-catenin, which inhibit the expression of Glut4, PPARgamma and C/EBPalpha. The compound reduced the expression time of C/EBPbeta and C/EBPdelta. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARgamma or C/EBPalpha because of the reduced expression time of C/EBPbeta and C/EBPdelta.
Katsuhiko Minamino; Yuri Yanaga; Masaru Ohtsuru
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  54     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-18     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  250-4     Citation Subset:  IM    
Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University, Nishinomiya, Japan.
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MeSH Terms
Adipocytes / metabolism*
Blotting, Western
CCAAT-Enhancer-Binding Protein-beta / drug effects*,  genetics,  metabolism
CCAAT-Enhancer-Binding Protein-delta / drug effects*,  genetics,  metabolism
Cell Culture Techniques
Cell Differentiation / genetics
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation / genetics
Grifola* / chemistry
Plant Extracts / isolation & purification,  pharmacology*
Reg. No./Substance:
0/CCAAT-Enhancer-Binding Protein-beta; 0/Plant Extracts; 142662-43-9/CCAAT-Enhancer-Binding Protein-delta

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