| Bioactive saponins and glycosides. II. Senegae Radix. (2): Chemical structures, hypoglycemic activity, and ethanol absorption-inhibitory effect of E-senegasaponin c, Z-senegasaponin c, and Z-senegins II, III, and IV. | |
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MedLine Citation:
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PMID: 8706138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following the characterization of E-senegasaponins a and b and Z-senegasaponins a and b, new bioactive saponins named E-senegasaponin c and Z-senegasaponin c were isolated from Senegae Radix, the root of Polygala senega L. var. latifolia TORREY et GRAY., together with Z-senegins II, III, and IV. The chemical structures of E and Z-senegasaponins c and Z-senegins II, III, and IV were elucidated on the basis of chemical and physicochemical evidence, and the geometrical isomeric structures of the 4"-methoxycinnamoyl and 3",4"-dimethoxycinnamoyl groups in these saponins were found to show tautomer-like behavior under irradiation with fluorescent lamps. E and Z-Senegasaponins c and E and Z-senegins II, III, and IV were found to exhibit hypoglycemic activity in the oral D-glucose tolerance test. (E) and (Z)-Senegins II also showed an inhibitory effect on alcohol absorption in rats. |
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Authors:
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M Yoshikawa; T Murakami; H Matsuda; T Ueno; M Kadoya; J Yamahara; N Murakami |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 44 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-09-12 Completed Date: 1996-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1305-13 Citation Subset: IM |
Affiliation:
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Kyoto Pharmaceutical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption
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drug effects Animals Ethanol / metabolism* Glycosides / chemistry, isolation & purification*, pharmacology* Hypoglycemic Agents / pharmacology* Magnetic Resonance Spectroscopy Male Plant Extracts / pharmacology Rats Rats, Wistar Saponins / chemistry, isolation & purification*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Glycosides; 0/Hypoglycemic Agents; 0/Plant Extracts; 0/Saponins; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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