Document Detail

Bioactive lipids and their receptors.
MedLine Citation:
PMID:  12630293     Owner:  NLM     Status:  MEDLINE    
Recent studies show that several, if not all, degradative products of glycerol- and sphingosine-based lipids are active molecules that play important roles in different signal transduction pathways. The functions and actions of lysophosphatidic acid and sphingosine 1-phosphate, the degradation products of phospholipids and sphingolipids, respectively, have received a great deal of attention during the past few years. These lipid mediators are active through several abundant G protein-coupled receptors that were recently identified and characterized. This review will discuss recent achievements in the area of bioactive lipids.
Itzchak Angel; Adina Bar; Rachel Haring
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in drug discovery & development     Volume:  5     ISSN:  1367-6733     ISO Abbreviation:  Curr Opin Drug Discov Devel     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2003-03-12     Completed Date:  2003-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100887519     Medline TA:  Curr Opin Drug Discov Devel     Country:  England    
Other Details:
Languages:  eng     Pagination:  728-40     Citation Subset:  IM    
D-Pharm Ltd, Kiryat Weizmann Science Park, PO Box 2313, Rehovot 76123, Israel.
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MeSH Terms
Lipids / pharmacology*
Prostaglandins / pharmacology
Receptors, Drug / drug effects*
Signal Transduction / drug effects
Sphingolipids / pharmacology
Reg. No./Substance:
0/Lipids; 0/Prostaglandins; 0/Receptors, Drug; 0/Sphingolipids
Erratum In:
Curr Opin Drug Discov Devel. 2002 Nov;5(6):1009

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