Document Detail

Bioactive glasses-incorporated, core-shell-structured polypeptide/polysaccharide nanofibrous hydrogels.
MedLine Citation:
PMID:  23218343     Owner:  NLM     Status:  In-Data-Review    
Although the synthetic hydrogel materials capable of accelerating wound healing are being developed at a rapid pace, achieving inorganic-organic hybrid at nanoscale dimension in nanofibrous hydrogels is still a great challenge because of its notorious brittleness and microstructural stability in wet state. Here, we developed a new nanofibrous gelatin/bioactive glass (NF-GEL/BG) composite hydrogel by phase separation method and followed by arming the nanofibers network with counterionic chitosan-hyaluronic acid pairs for improving microstructural and thermal integrity. We achieve this feature by carrying an optimal balance of charges that allows the inorganic ion release in aqueous solution without minimal structure collapse. Therefore, such NF-GEL-based, polysaccharide-crosslinked bioactive hydrogel could afford a close biomimicry to the fibrous nanostructure and constituents of the hierarchically organized natural soft tissues to facilitate chronic, nonhealing wound treatment.
Jian Chen; Xiaoyi Chen; Xianyan Yang; Chunmao Han; Changyou Gao; Zhongru Gou
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Publication Detail:
Type:  Journal Article     Date:  2012-10-03
Journal Detail:
Title:  Carbohydrate polymers     Volume:  92     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  England    
Other Details:
Languages:  eng     Pagination:  612-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Surgery, The 2nd Affiliated Hospital, Zhejiang University of School of Medicine, Hangzhou 310009, China.
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