Document Detail


Bioactive food components and cancer-specific metabonomic profiles.
MedLine Citation:
PMID:  21113295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cancer cells possess unique metabolic signatures compared to normal cells, including shifts in aerobic glycolysis, glutaminolysis, and de novo biosynthesis of macromolecules. Targeting these changes with agents (drugs and dietary components) has been employed as strategies to reduce the complications associated with tumorigenesis. This paper highlights the ability of several food components to suppress tumor-specific metabolic pathways, including increased expression of glucose transporters, oncogenic tyrosine kinase, tumor-specific M2-type pyruvate kinase, and fatty acid synthase, and the detection of such effects using various metabonomic technologies, including liquid chromatography/mass spectrometry (LC/MS) and stable isotope-labeled MS. Stable isotope-mediated tracing technologies offer exciting opportunities for defining specific target(s) for food components. Exposures, especially during the early transition phase from normal to cancer, are critical for the translation of knowledge about food components into effective prevention strategies. Although appropriate dietary exposures needed to alter cellular metabolism remain inconsistent and/or ill-defined, validated metabonomic biomarkers for dietary components hold promise for establishing effective strategies for cancer prevention.
Authors:
Young S Kim; John A Milner
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-11-11
Journal Detail:
Title:  Journal of biomedicine & biotechnology     Volume:  2011     ISSN:  1110-7251     ISO Abbreviation:  J. Biomed. Biotechnol.     Publication Date:  2011  
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-03-31     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101135740     Medline TA:  J Biomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  721213     Citation Subset:  IM    
Affiliation:
Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Liquid / methods
Diet
Fatty Acid Synthetase Complex / metabolism
Food*
Glucose / metabolism
Glycolysis
Health Promotion / methods
Humans
Mass Spectrometry / methods
Metabolomics / methods*
Mice
Neoplasms / metabolism*,  prevention & control
Pentose Phosphate Pathway
Protein-Tyrosine Kinases / metabolism
Chemical
Reg. No./Substance:
50-99-7/Glucose; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 6.-/Fatty Acid Synthetase Complex
Comments/Corrections

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