| Bioactive borate glass scaffolds: in vitro and in vivo evaluation for use as a drug delivery system in the treatment of bone infection. | |
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MedLine Citation:
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PMID: 19830527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this work was to evaluate borate bioactive glass scaffolds (with a composition in the system Na(2)O-K(2)O-MgO-CaO-B(2)O(3)-P(2)O(5)) as devices for the release of the drug Vancomycin in the treatment of bone infection. A solution of ammonium phosphate, with or without dissolved Vancomycin, was used to bond borate glass particles into the shape of pellets. The in vitro degradation of the pellets and their conversion to a hydroxyapatite-type material in a simulated body fluid (SBF) were investigated using weight loss measurements, chemical analysis, X-ray diffraction, and scanning electron microscopy. The results showed that greater than 90% of the glass in the scaffolds degraded within 1 week, to form poorly crystallized hydroxyapatite (HA). Pellets loaded with Vancomycin provided controlled release of the drug over 4 days. Vancomycin-loaded scaffolds were implanted into the right tibiae of rabbits infected with osteomyelitis. The efficacy of the treatment was assessed using microbiological examination and histology. The HA formed in the scaffolds in vivo, resulting from the conversion of the glass, served as structure to support the growth of new bone and blood vessels. The results in this work indicate that bioactive borate glass could provide a promising biodegradable and bioactive material for use as both a drug delivery system and a scaffold for bone repair. |
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Authors:
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Xin Liu; Zongping Xie; Changqing Zhang; Haobo Pan; Mohamed N Rahaman; Xin Zhang; Qiang Fu; Wenhai Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-15 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 21 ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-11 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 575-82 Citation Subset: IM |
Affiliation:
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Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai, 200092, People's Republic of China. tsliuxin@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / administration & dosage, chemistry Borates / chemistry* Drug Compounding / methods Drug Implants / chemistry*, therapeutic use* Equipment Failure Analysis Materials Testing Osteomyelitis / therapy* Rabbits Tissue Scaffolds* Treatment Outcome Vancomycin / administration & dosage*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Borates; 0/Drug Implants; 1404-90-6/Vancomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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