Document Detail


Bioactive hydroperoxyl cembranoids from the Red Sea soft coral Sarcophyton glaucum.
MedLine Citation:
PMID:  22363231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P₄₅₀ 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
Authors:
Mohamed-Elamir F Hegazy; Amira M Gamal Eldeen; Abdelaaty A Shahat; Fathy F Abdel-Latif; Tarik A Mohamed; Bruce R Whittlesey; Paul W Paré
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-18
Journal Detail:
Title:  Marine drugs     Volume:  10     ISSN:  1660-3397     ISO Abbreviation:  Mar Drugs     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101213729     Medline TA:  Mar Drugs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  209-22     Citation Subset:  IM    
Affiliation:
Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthozoa / chemistry*
Anticarcinogenic Agents / chemistry,  isolation & purification*,  pharmacology
Circular Dichroism
Diterpenes / chemistry,  isolation & purification*,  pharmacology
Indian Ocean
Magnetic Resonance Spectroscopy
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Diterpenes
Comments/Corrections

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