| Bioactivation of herbal constituents: simple alerts in the complex system. | |
| | |
MedLine Citation:
|
PMID: 21609190 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: The elucidation of the toxicological mechanisms of herbal medicines is becoming more and more important with the increasing application of herbal medicines, for treatment of various diseases and the promotion of health. Furthermore, it is widely recognized that as herbal components undergo bioactivation, there is a critical need for a greater understanding of herbal toxicity induction. Areas covered: This article summarizes the current understanding of structural alerts present in herbal remedies as well as the herbs' and individuals' factors, complicating the interpretation of herbal toxicity via bioactivation. Medline (by means of PubMed up to July 2010) has been searched using proper relevant terms. The reader is provided with reported examples of herbal bioactivation based on toxicophores, which are summarized in an extended list. The article also discusses the factors which influence the herbal bioactivation study, including herbal complexity, competitive detoxification metabolism pathways as well as the individual and species difference of drug metabolizing enzymes and intestinal factors. Expert opinion: The early evaluation of the bioactivation potential of herbal components is helpful for providing alerts of herbal toxicity. However, the potential toxic effects should be considered in the context of the complex systems of herbs and the individual patient. |
| | |
Authors:
|
Zhong-Ze Fang; Yan-Yan Zhang; Xiu-Li Wang; Yun-Feng Cao; Hong Huo; Ling Yang |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-24 |
Journal Detail:
|
Title: Expert opinion on drug metabolism & toxicology Volume: - ISSN: 1744-7607 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101228422 Medline TA: Expert Opin Drug Metab Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Laboratory of Pharmaceutical Resource Discovery, Dalian, 116023 , China +86 411 84379317 ; +86 411 84676961 ; yling@dicp.ac.cn. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fentanyl nasal spray for the treatment of cancer pain.
Next Document: Carboxylesterase inhibitors.