Document Detail


Bioaccumulation and maternal transfer of PBDE 47 in the marine medaka (Oryzias melastigma) following dietary exposure.
MedLine Citation:
PMID:  21481818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bioaccumulation and maternal transfer of 2,2',4,4'-tetrabromodiphenyl ether (PBDE 47) were investigated in the marine medaka (Oryzias melastigma) following dietary exposure, in which PBDE 47 was bioencapsulated into brine shrimp (Artemia sp.) and fed daily to male-female pairs of medaka. In the accumulation experiment, each 2-month-old (pre-breeding) medaka were provided with dietary PBDE 47 at 1.3±0.2 μg/day for 21 days. Growth-corrected concentrations of PBDE 47 in the medaka increased over the 21 days of exposure and there were no significant differences between males and females at any of the sampling times. Final concentrations were similar for males and females after 21 days (230±30 and 250±30 μgg(-1) wet weight, respectively), accounting for 84-100% of the PBDE 47 provided in the diet. In the maternal transfer experiment, 3-month-old (breeding) medaka were provided with dietary PBDE 47 at 1.2±0.2 μg/day for 18 days, and reached body concentrations of 76±3 (males) and 61±6 (females)μgg(-1) wet weight. Female growth-corrected PBDE 47 concentrations were significantly lower than males by day 12 (P<0.05), and egg PBDE 47 concentrations were up to 25 ng/egg by day 18. Our results showed that maternal transfer is an important offloading mechanism for female fish. The fact that lipid normalized egg:female PBDE ratios did not significantly deviate from 1 further indicated that the maternal transfer of PBDE 47 is associated with lipid mobilization during egg production.
Authors:
Jason P van de Merwe; Alice K Y Chan; Elva N Y Lei; M S Yau; Michael H W Lam; Rudolf S S Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-04
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  103     ISSN:  1879-1514     ISO Abbreviation:  Aquat. Toxicol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-10     Completed Date:  2011-08-08     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Centre for Marine Environmental Research and Innovative Technology, City University of Hong Kong, Kowloon, Hong Kong, China.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Embryo, Nonmammalian / metabolism
Environmental Exposure / adverse effects
Female
Halogenated Diphenyl Ethers / metabolism*
Male
Oryzias / embryology,  metabolism*
Water Pollutants, Chemical / metabolism*
Chemical
Reg. No./Substance:
0/Halogenated Diphenyl Ethers; 0/Water Pollutants, Chemical; 0N97R5X10X/2,2',4,4'-tetrabromodiphenyl ether

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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