Document Detail

Bioaccessibility of pistachio polyphenols, xanthophylls, and tocopherols during simulated human digestion.
MedLine Citation:
PMID:  23237656     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The bioaccessibility of bioactives from pistachios has not been previously evaluated. In the present study we quantified the release of polyphenols, xanthophylls (lutein), and tocopherols from pistachios (raw pistachios, roasted salted pistachios, and muffins made with raw pistachios) during simulated human digestion.
METHODS: A dynamic gastric model of digestion that provides a realistic and predictive simulation of the physical and chemical processing and accurately mimics the residence time and the luminal environment within the human stomach was used for the digestion studies.
RESULTS: More than 90% of the polyphenols were released in the gastric compartment, with virtually total release in the duodenal phase. No significant differences were observed between raw shelled and roasted salted pistachio. The presence of a food matrix (muffin) decreased the bioaccessibility of protocatechuic acid (78%) and luteolin (36%). Almost 100% bioaccessibility of lutein and tocopherols was found after duodenal digestion, with no difference among the three samples.
CONCLUSION: The rapid release of the assayed bioactives in the stomach maximizes the potential for absorption in the duodenum and contributes to the beneficial relation between pistachio consumption and health-related outcomes.
Giuseppina Mandalari; Carlo Bisignano; Angela Filocamo; Simona Chessa; Mariagiovanna Sarò; Germana Torre; Richard M Faulks; Paola Dugo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  29     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
The Model Gut, Institute of Food Research, Norwich, United Kingdom; Pharmaco-Biological Department, University of Messina, Messina, Italy. Electronic address:
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