Document Detail

Bio-techniques for the detection of genetic toxicity in the aquatic environment.
MedLine Citation:
PMID:  1367097     Owner:  NLM     Status:  MEDLINE    
This article reviews the application of sensitive biotechniques in the detection of DNA damage within the aquatic environment as "early warning" indicators of pollution-related genetic toxicity. Bacterial mutagenicity assays have played an important role both in the discovery of mutagens and in the analysis of the ability of aquatic organisms to convert inert substances to reactive genotoxic products. Genetic damage in aquatic species treated with carcinogens has been detected by analysis of DNA adducts, induction of DNA repair, DNA strand breakage and formation of chromosomal aberrations and sister chromatid exchanges. Little information is available on pollution-related DNA damage resulting from field exposure. A 32P-postlabelling technique for the sensitive detection of DNA adducts is a promising development towards this aim and the analysis of changes in oncogene nucleotide sequence in tumour tissue is considered an important future direction.
J K Chipman; J W Marsh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of biotechnology     Volume:  17     ISSN:  0168-1656     ISO Abbreviation:  J. Biotechnol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8411927     Medline TA:  J Biotechnol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-208     Citation Subset:  B    
School of Biochemistry, University of Birmingham, Edgbaston, U.K.
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MeSH Terms
Chromosome Aberrations
DNA / metabolism
DNA Damage
DNA Repair
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Mutagens; 0/Water Pollutants, Chemical; 9007-49-2/DNA

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