Document Detail


Bio-techniques for the detection of genetic toxicity in the aquatic environment.
MedLine Citation:
PMID:  1367097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article reviews the application of sensitive biotechniques in the detection of DNA damage within the aquatic environment as "early warning" indicators of pollution-related genetic toxicity. Bacterial mutagenicity assays have played an important role both in the discovery of mutagens and in the analysis of the ability of aquatic organisms to convert inert substances to reactive genotoxic products. Genetic damage in aquatic species treated with carcinogens has been detected by analysis of DNA adducts, induction of DNA repair, DNA strand breakage and formation of chromosomal aberrations and sister chromatid exchanges. Little information is available on pollution-related DNA damage resulting from field exposure. A 32P-postlabelling technique for the sensitive detection of DNA adducts is a promising development towards this aim and the analysis of changes in oncogene nucleotide sequence in tumour tissue is considered an important future direction.
Authors:
J K Chipman; J W Marsh
Related Documents :
11113997 - Toxicity and genotoxicity of antimalarial alkaloid rich extracts derived from mitragyna...
2492077 - Polychlorinated biphenyls (pcbs): mutagenicity and carcinogenicity.
6522667 - Toxicity, tumor promotion, and carcinogenesis in relation to excessive dosage.
15489137 - Genetic alterations and dna repair in human carcinogenesis.
21787617 - Protection of dna and membrane from γ-radiation induced damage by the extract of acorus...
19931607 - Microcalorimetric and spectrographic studies on the interaction of dna with betaxolol.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of biotechnology     Volume:  17     ISSN:  0168-1656     ISO Abbreviation:  J. Biotechnol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8411927     Medline TA:  J Biotechnol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-208     Citation Subset:  B    
Affiliation:
School of Biochemistry, University of Birmingham, Edgbaston, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations
DNA / metabolism
DNA Damage
DNA Repair
Mutagens*
Water Pollutants, Chemical / toxicity*
Chemical
Reg. No./Substance:
0/Mutagens; 0/Water Pollutants, Chemical; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Studying DNA-protein interactions using NMR.
Next Document:  Electrically controlled proliferation of human carcinoma cells cultured on the surface of an electro...