| Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid - Collagen conjugate for neural interfacing. | |
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MedLine Citation:
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PMID: 21477859 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this work, polydimethylsiloxane was activated with oxygen plasma and treated with silanes bearing ethylene imine units. Hyaluronic acid was then grafted covalently onto the aminated surfaces. The influence of silane structure on surface amination was assessed and the influence of the modification on surface physiochemical properties and protein adsorption of modified polydimethylsiloxane were investigated. Collagen type I was conjugated onto the modified polydimethylsiloxane to improve its cyto-compatibility for neural applications. In vitro cultivation of rat pheochromocytoma cells on the bioactive polydimethylsiloxane showed a significant increase in cell growth and differentiation. The potential applications of the bio-functionalized polydimethylsiloxane in cochlear implant electrode arrays were discussed. |
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Authors:
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Zhilian Yue; Xiao Liu; Paul J Molino; Gordon G Wallace |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-7 |
Journal Detail:
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Title: Biomaterials Volume: - ISSN: 1878-5905 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM facility, University of Wollongong, NSW 2522, Australia; The HEARing CRC, Carlton, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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