Document Detail


Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid - Collagen conjugate for neural interfacing.
MedLine Citation:
PMID:  21477859     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this work, polydimethylsiloxane was activated with oxygen plasma and treated with silanes bearing ethylene imine units. Hyaluronic acid was then grafted covalently onto the aminated surfaces. The influence of silane structure on surface amination was assessed and the influence of the modification on surface physiochemical properties and protein adsorption of modified polydimethylsiloxane were investigated. Collagen type I was conjugated onto the modified polydimethylsiloxane to improve its cyto-compatibility for neural applications. In vitro cultivation of rat pheochromocytoma cells on the bioactive polydimethylsiloxane showed a significant increase in cell growth and differentiation. The potential applications of the bio-functionalized polydimethylsiloxane in cochlear implant electrode arrays were discussed.
Authors:
Zhilian Yue; Xiao Liu; Paul J Molino; Gordon G Wallace
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-7
Journal Detail:
Title:  Biomaterials     Volume:  -     ISSN:  1878-5905     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM facility, University of Wollongong, NSW 2522, Australia; The HEARing CRC, Carlton, Australia.
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