Document Detail


Bio-energetic changes in human gastrocnemius muscle 1-2 days after strenuous exercise.
MedLine Citation:
PMID:  1442119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[31P]magnetic resonance spectroscopy was used to study the metabolic sequelae of intense muscular activity in gastrocnemius of seven subjects 1-2 days after a 67-mile bicycle ride. The muscle was examined at rest, during a test exercise and during recovery from test exercise. Post-ride and pre-ride results were compared. At rest, the ratio of phosphocreatine to ATP (PCr/ATP) was increased post-ride; during test exercise PCr/(PCr+Pi) was lower post-ride; and the recoveries of PCr, Pi and PCr/(PCr+Pi) after test exercise were delayed, with decreased 'overshoot' of PCr/(PCr+Pi) (which is due to recovery of Pi to below its resting value). Mild mitochondrial damage (perhaps due to exposure to high cytosolic [Pi] during the bicycle ride) may explain some of these results. In contrast to reports of largely eccentric exercise there was no increase in resting Pi/ATP. We have thus demonstrated perturbations of muscle bio-energetics 1-2 days after strenuous exercise, in the absence of convincing enzymological evidence of muscle damage.
Authors:
G J Kemp; D J Taylor; G K Radda; B Rajagopalan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  146     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-07     Completed Date:  1992-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM; S    
Affiliation:
MRC Clinical and Biochemical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspartate Aminotransferases / blood
Creatine Kinase / blood
Energy Metabolism / physiology*
Exercise / physiology*
Female
Humans
Magnetic Resonance Spectroscopy
Male
Mitochondria, Muscle / metabolism,  physiology
Muscles / metabolism*
Chemical
Reg. No./Substance:
EC 2.6.1.1/Aspartate Aminotransferases; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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