Document Detail

Binge-like eating in mice.
MedLine Citation:
PMID:  19130488     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Given the lack of reliable murine model of binge-like eating, we tried to induce this pathological behavior in mice. METHOD: We used an experimental protocol mimicking the etiological factors involved in the development of binge eating in humans, that is, food restriction, refeeding (R-R) in presence of high palatable food, and stress (S). RESULTS: Mice subjected to at least three cycles of R-R plus S (forced swimming stress), showed a binge-like behavior evident as early as 4 h, persisting 24 h after stress application and not associated to depressive-like behavior. However, after the third R-R/S cycle, food intakes of mice returned to normal levels. DISCUSSION: (i) at least three cycles of R-R plus S are required to promote abnormal eating in mice, (ii) this is not associated to depressive-like behaviors, and (iii) the enhanced pathological behavior showed a transient nature not persisting after the third R-R/S cycle.
Daniele Consoli; Angelo Contarino; Antoine Tabarin; Filippo Drago
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of eating disorders     Volume:  42     ISSN:  1098-108X     ISO Abbreviation:  Int J Eat Disord     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-8     Citation Subset:  IM    
Department of Experimental and Clinical Pharmacology, Medical School, University of Catania, Catania, Italy.
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MeSH Terms
Disease Models, Animal*
Energy Intake
Food Deprivation / physiology
Food Preferences
Mice, Inbred C57BL
Random Allocation
Stress, Physiological
Stress, Psychological / physiopathology

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