| Binge eating in rats produced by combining dieting with stress. | |
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MedLine Citation:
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PMID: 18428649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This unit describes a rodent model of binge eating based on cyclic restriction, refeeding, footshock, and intermittent access to palatable food. These conditions mimic dieting, stress, and "junk" food indulgence, respectively, all common etiological and maintenance factors in human binge eating. Four groups of rats are used: one subjected to cyclic food restriction, another to acute footshock stress, another to both of these (R + S), and a control. Neither cyclic restriction nor stress alone produces binge eating, but the R + S rats, despite satiety, double their intake of palatable food in a discrete period of time (i.e., binge) when stressed. This protocol recapitulates critical properties of human binge eating, namely preference for palatable food, dieting- and stress-induced vulnerability to binging, and eating for reward versus metabolic need. This protocol permits study of the psychobiological underpinnings of binge eating and possibly also of addiction, impulsivity, and depression, which are co-morbid with binge eating. |
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Authors:
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Mary M Boggiano; Paula C Chandler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] Volume: Chapter 9 ISSN: 1934-8576 ISO Abbreviation: Curr Protoc Neurosci Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2008-04-22 Completed Date: 2008-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706581 Medline TA: Curr Protoc Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: Unit9.23A Citation Subset: IM |
Affiliation:
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University of Alabama at Birmingham, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal Bulimia / etiology* Caloric Restriction / methods Diet / adverse effects* Disease Models, Animal Eating / physiology Electroshock / adverse effects Feeding Behavior / physiology Female Rats Rats, Sprague-Dawley Restraint, Physical / methods Stress, Psychological / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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