Document Detail

Binge eating in rats produced by combining dieting with stress.
MedLine Citation:
PMID:  18428649     Owner:  NLM     Status:  MEDLINE    
This unit describes a rodent model of binge eating based on cyclic restriction, refeeding, footshock, and intermittent access to palatable food. These conditions mimic dieting, stress, and "junk" food indulgence, respectively, all common etiological and maintenance factors in human binge eating. Four groups of rats are used: one subjected to cyclic food restriction, another to acute footshock stress, another to both of these (R + S), and a control. Neither cyclic restriction nor stress alone produces binge eating, but the R + S rats, despite satiety, double their intake of palatable food in a discrete period of time (i.e., binge) when stressed. This protocol recapitulates critical properties of human binge eating, namely preference for palatable food, dieting- and stress-induced vulnerability to binging, and eating for reward versus metabolic need. This protocol permits study of the psychobiological underpinnings of binge eating and possibly also of addiction, impulsivity, and depression, which are co-morbid with binge eating.
Mary M Boggiano; Paula C Chandler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]     Volume:  Chapter 9     ISSN:  1934-8576     ISO Abbreviation:  Curr Protoc Neurosci     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706581     Medline TA:  Curr Protoc Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  Unit9.23A     Citation Subset:  IM    
University of Alabama at Birmingham, USA.
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MeSH Terms
Behavior, Animal
Bulimia / etiology*
Caloric Restriction / methods
Diet / adverse effects*
Disease Models, Animal
Eating / physiology
Electroshock / adverse effects
Feeding Behavior / physiology
Rats, Sprague-Dawley
Restraint, Physical / methods
Stress, Psychological / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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