Document Detail


Binge eating and fast cognitive worsening in an early-onset bvFTD patient carrying C9ORF72 expansion.
MedLine Citation:
PMID:  25158292     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An expanded hexanucleotide (GGGGCC) repeat in a non-coding promoter region of open reading frame 72 of chromosome 9 (C9ORF72) has been recently identified as a major cause of familial and sporadic frontotemporal lobar degeneration. We describe the clinical picture of a 64-year-old woman carrying the hexanucleotide repeat expansion, who developed a sporadic early-onset form of behavioral variant frontotemporal dementia characterized by the occurrence of uncommon behavioral manifestations such as binge eating disturbance and by a rapid worsening of cognitive abilities. Our report confirms previous studies asserting that C9ORF72 repeats may sustain heterogeneous clinical syndromes.
Authors:
G Talarico; M Canevelli; G Tosto; P Piscopo; A Confaloni; D Galimberti; C Fenoglio; E Scarpini; M Gasparini; G Bruno
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-26
Journal Detail:
Title:  Neurocase     Volume:  -     ISSN:  1465-3656     ISO Abbreviation:  Neurocase     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9511374     Medline TA:  Neurocase     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
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