| Binge drinking in pregnancy and risk of fetal death. | |
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MedLine Citation:
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PMID: 18310362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether the frequency and timing of binge drinking episodes (intake of five or more drinks on one occasion) during the first 16 weeks of pregnancy increase the risk of fetal death. METHODS: The study is based upon data from 89,201 women who were enrolled in the Danish National Birth Cohort from 1996 to 2002 and participated in an interview that took place in midpregnancy (n=86,752) or after a fetal loss (n=2,449). In total, 3,714 pregnancies resulted in fetal death. Data were analyzed by means of Cox regression models. RESULTS: Neither the frequency nor the timing of binge episodes was related to the risk of early (at or before 12 completed weeks) or late (13-21 completed weeks) spontaneous abortion. However, three or more binge episodes showed an adjusted hazard ratio of 1.56 (95% confidence interval 1.01-2.40) for stillbirth (22 or more completed weeks) relative to nonbinge drinkers. Women with an average intake of three or more drinks per week and two or more binge drinking episodes had a hazard ratio of 2.20 (95% confidence interval 1.73-2.80) compared with women with no average intake and no binge drinking. CONCLUSION: Binge drinking three or more times during pregnancy is associated with an increased risk of stillbirth, but neither frequency nor timing of binge drinking was associated with an increased risk of spontaneous abortion in clinically recognized pregnancies. |
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Authors:
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Katrine Strandberg-Larsen; Naja Rod Nielsen; Morten Grønbaek; Per Kragh Andersen; Jørn Olsen; Anne-Marie Nybo Andersen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 111 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-04-24 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 602-9 Citation Subset: AIM; IM |
Affiliation:
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Centre for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. kal@niph.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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adverse effects* Central Nervous System Depressants / adverse effects* Cohort Studies Denmark Ethanol / poisoning* Female Fetal Death / epidemiology, etiology* Humans Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Proportional Hazards Models Risk Stillbirth / epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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