Document Detail


Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes.
MedLine Citation:
PMID:  22579533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: While the study of binge eating disorder (BED) has burgeoned in the past decade, an understanding of its neurobiological underpinnings is still in the early stages. Previous research suggests that BED may be an overeating syndrome characterized by a hyper-responsiveness to reward, and a strong dopamine signaling in the neuro-circuitry that regulates pleasure and appetitive behaviors. We investigated the D2 receptors genes (DRD2/ANKK1) and their relation to the BED phenotype and four sub-phenotypes of BED that reflect an enhanced response to positive food stimuli.
METHODS: In a sample of 230 obese adults with and without BED, we genotyped five functional markers of the D2 receptor: rs1800497, rs1799732, rs2283265, rs12364283, and rs6277, and assessed binge eating, emotional eating, hedonic eating, and food craving from dimensionally-scored, self-report questionnaires.
RESULTS: Compared to weight-matched controls, BED was significantly related to the rs1800497 and rs6277 genotypes that reflect enhanced dopamine neurotransmission. BED participants were also less likely to carry the minor T allele of rs2283265. The same markers related to the sub-phenotypes of BED with rs1800497 showing the strongest effects in the predicted direction.
CONCLUSIONS: This study supports the view that BED may be a condition that has its causal origins in a hypersensitivity to reward - a predisposition that is likely to foster overeating in our current environment with abundant availability of highly palatable and calorically-dense processed foods.
Authors:
Caroline Davis; Robert D Levitan; Zeynep Yilmaz; Allan S Kaplan; Jacqueline C Carter; James L Kennedy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-08
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  38     ISSN:  1878-4216     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2013-01-21     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Binge-Eating Disorder / complications,  genetics*,  psychology
Bulimia / complications,  genetics*,  psychology
Feeding Behavior / physiology*,  psychology
Female
Genotype*
Humans
Male
Middle Aged
Obesity / complications,  genetics,  psychology
Phenotype*
Questionnaires
Receptors, Dopamine D2 / genetics*
Reward
Grant Support
ID/Acronym/Agency:
MOP‐84257//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Receptors, Dopamine D2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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