Document Detail


Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood.
MedLine Citation:
PMID:  21571252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Administration of cocaine during adolescence alters neurotransmission and behavioral sensitization in adulthood, but the effect on the acquisition of fear memories and the development of emotion-based neuronal circuits is unknown.
METHODS: We examined fear learning and anxiety-related behaviors in adult male rats that were subjected to binge cocaine treatment during adolescence. We furthermore conducted gene expression analyses of the amygdala 22 hours after the last cocaine injection to identify molecular patterns that might lead to altered emotional processing.
RESULTS: Rats injected with cocaine during adolescence displayed less anxiety in adulthood than their vehicle-injected counterparts. In addition, cocaine-exposed animals were deficient in their ability to develop contextual fear responses. Cocaine administration caused transient gene expression changes in the Wnt signaling pathway, of axon guidance molecules, and of synaptic proteins, suggesting that cocaine perturbs dendritic structures and synapses in the amygdala. Phosphorylation of glycogen synthase kinase 3 beta, a kinase in the Wnt signaling pathway, was altered immediately following the binge cocaine paradigm and returned to normal levels 22 hours after the last cocaine injection.
CONCLUSIONS: Cocaine exposure during adolescence leads to molecular changes in the amygdala and decreases fear learning and anxiety in adulthood.
Authors:
Stephanie E Sillivan; Yolanda D Black; Alipi V Naydenov; Fair R Vassoler; Ryan P Hanlin; Christine Konradi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-05-14
Journal Detail:
Title:  Biological psychiatry     Volume:  70     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-25     Completed Date:  2012-01-09     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  583-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Amygdala / metabolism*
Animals
Anxiety / drug therapy*
Cocaine / poisoning*
Disease Models, Animal
Fear / drug effects*
Gene Expression / drug effects*
Glycogen Synthase Kinase 3 / metabolism
Learning / drug effects
Male
Rats
Rats, Sprague-Dawley
Wnt Signaling Pathway / drug effects*
Grant Support
ID/Acronym/Agency:
DA19152/DA/NIDA NIH HHS; R21 DA019152/DA/NIDA NIH HHS; R21 DA019152-01/DA/NIDA NIH HHS; T32MH064913/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.11.1/glycogen synthase kinase 3 beta; EC 2.7.11.26/Glycogen Synthase Kinase 3; I5Y540LHVR/Cocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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