Document Detail

Binding of technetium-99m to plasma proteins: influence on the distribution of Tc-99m phosphate agents.
MedLine Citation:
PMID:  7431108     Owner:  NLM     Status:  MEDLINE    
Plasma protein binding of Tc-99m was assessed in man after injection of various Tc-99m-labeled bone imaging agents. Of the five methods in which plasma proteins were precipitated to determine protein binding no correlation between them could be established. The ammonium sulfate method seemed to correlate well with dialysis filtration. Plasma obtained from patients injected with Tc-99m phosphate compounds was reinjected to rats. The bone uptake in these animals correlated linearly with the unbound activity in the injected plasma. Provided that no protein binding would occur, the bone uptake as well as the urinary excretion proved to be identical for Tc-99m HEDP, MDP, and PPi. Electrophoresis of Tc-99m PPi indicated that the intact complex may be uncharged, whereas at low ligand concentrations uncharged as well as negatively charged Tc-99m species are formed. Better methods are needed, however, to establish the presence of various Tc-99m species and their relative role in the kinetics of these compounds, and plasma protein binding.
C Schümichen; K Koch; A Kraus; G Kuhlicke; K Weiler; A Wenn; G Hoffman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  21     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1080-5     Citation Subset:  IM    
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MeSH Terms
Blood Proteins / metabolism*
Bone and Bones / metabolism
Phosphates / metabolism*
Protein Binding
Technetium / blood,  metabolism*
Time Factors
Tissue Distribution
Reg. No./Substance:
0/Blood Proteins; 0/Phosphates; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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