Document Detail


Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis.
MedLine Citation:
PMID:  2897467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relative binding affinities of over 30 steroids have been measured for the cytosol glucocorticoid receptor (GR) of thymus, liver, and hepatoma tissue culture cells and for progestin, androgen, and mineralocorticoid receptors. The data have been analyzed by correspondence analysis to reveal the singularities among the receptors of different hormonal classes, the similarities in GR of different origins, and the different specificities of the ligands. Additional data on new steroids have been injected into the system as well as results on a further parameter, namely the induction of tyrosine aminotransferase (TAT) activity, to illustrate the power and flexibility of the methodology. The analysis has confirmed previous correlations between GR binding and TAT response but also highlighted the antiglucocorticoid activity of progestins. This method should prove to be a substantial aid to the interpretation of increasingly complex data, in particular with regard to the action of existing and newly synthesized steroids on glucocorticoid systems of differential sensitivity.
Authors:
T Ojasoo; J C Doré; J Gilbert; J P Raynaud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  31     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-30     Completed Date:  1988-06-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1160-9     Citation Subset:  IM    
Affiliation:
Roussel-Uclaf, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Enzyme Induction
Glucocorticoids / antagonists & inhibitors
Male
Rabbits
Rats
Receptors, Androgen / metabolism
Receptors, Glucocorticoid / metabolism*
Receptors, Mineralocorticoid
Receptors, Progesterone / metabolism*
Receptors, Steroid / metabolism
Steroids / metabolism*
Tyrosine Transaminase / biosynthesis
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Receptors, Androgen; 0/Receptors, Glucocorticoid; 0/Receptors, Mineralocorticoid; 0/Receptors, Progesterone; 0/Receptors, Steroid; 0/Steroids; EC 2.6.1.5/Tyrosine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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