| Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis. | |
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MedLine Citation:
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PMID: 2897467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relative binding affinities of over 30 steroids have been measured for the cytosol glucocorticoid receptor (GR) of thymus, liver, and hepatoma tissue culture cells and for progestin, androgen, and mineralocorticoid receptors. The data have been analyzed by correspondence analysis to reveal the singularities among the receptors of different hormonal classes, the similarities in GR of different origins, and the different specificities of the ligands. Additional data on new steroids have been injected into the system as well as results on a further parameter, namely the induction of tyrosine aminotransferase (TAT) activity, to illustrate the power and flexibility of the methodology. The analysis has confirmed previous correlations between GR binding and TAT response but also highlighted the antiglucocorticoid activity of progestins. This method should prove to be a substantial aid to the interpretation of increasingly complex data, in particular with regard to the action of existing and newly synthesized steroids on glucocorticoid systems of differential sensitivity. |
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Authors:
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T Ojasoo; J C Doré; J Gilbert; J P Raynaud |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 31 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-06-30 Completed Date: 1988-06-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1160-9 Citation Subset: IM |
Affiliation:
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Roussel-Uclaf, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Enzyme Induction Glucocorticoids / antagonists & inhibitors Male Rabbits Rats Receptors, Androgen / metabolism Receptors, Glucocorticoid / metabolism* Receptors, Mineralocorticoid Receptors, Progesterone / metabolism* Receptors, Steroid / metabolism Steroids / metabolism* Tyrosine Transaminase / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Receptors, Androgen; 0/Receptors, Glucocorticoid; 0/Receptors, Mineralocorticoid; 0/Receptors, Progesterone; 0/Receptors, Steroid; 0/Steroids; EC 2.6.1.5/Tyrosine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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