Document Detail


Binding of staphylococcal enterotoxin A to accessory cells is a requirement for its ability to activate human T cells.
MedLine Citation:
PMID:  3258609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Staphylococcal enterotoxin A (SEA) activates human T cells at extremely low concentrations corresponding to 1 to 5 molecules/T cell. SEA, in contrast to other polyclonal activators, is absolutely dependent on accessory cells to interact with and activate T cells. Only cells that can bind SEA can act as accessory cells. Monocytes, B cells, and B lymphomas have these properties. Cells of the EBV-transformed B lymphoma Raji are particularly efficient as accessory cells. T cells do not bind soluble SEA. Probably the SEA molecule has to be attached to the accessory cell to become mitogenic. It is presently not known whether the T cell recognizes a molecular complex between the SEA molecule and the putative receptor moiety on the accessory cell or the SEA molecule itself modified by its binding to the accessory cell.
Authors:
R Carlsson; H Fischer; H O Sjögren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  140     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-18     Completed Date:  1988-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2484-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Tumour Immunology, University of Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Antigen-Presenting Cells / immunology,  metabolism*
Enterotoxins / metabolism*,  pharmacology
Humans
Lectins / pharmacology
Lymphocyte Activation / drug effects*
T-Lymphocytes / drug effects*,  immunology
Chemical
Reg. No./Substance:
0/Enterotoxins; 0/Lectins; 37337-57-8/enterotoxin A, Staphylococcal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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