Document Detail


Binding of serum ferritin to concanavalin A in patients with malignancy.
MedLine Citation:
PMID:  3790716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The percentage non-glycosylated, tissue type ferritin was measured in the serum of 30 cancer patients and 11 normal subjects, as well as in 10 tumour cytosols. As expected, in normal subjects the larger part of serum ferritin corresponded to glycosylated ferritin, and in tumour cytosols the larger part corresponded to non-glycosylated ferritin (tissue ferritin). In all but one cancer patients a significant part of the protein did not bind to Con A, thus behaving as tissue ferritin. The findings obtained suggest release of tissue type, non-glycosylated, ferritin by damaged cells or through abnormal secretion. This relative increase of the non-glycosylated ferritin fraction appears to be very frequently present in cancer, although not specific for it. Assaying for Con A binding may prove to be valuable in the study of malignant disease, and therefore deserves further investigation.
Authors:
L Muylle; P Blockx; D Becquart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  40     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-29     Completed Date:  1987-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  225-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Adult
Aged
Concanavalin A / blood*
Female
Ferritins / blood*
Humans
Kinetics
Male
Middle Aged
Neoplasms / blood*
Protein Binding
Transaminases / blood
Chemical
Reg. No./Substance:
11028-71-0/Concanavalin A; 9007-73-2/Ferritins; EC 2.6.1.-/Transaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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