Document Detail

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia.
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MedLine Citation:
PMID:  182894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term established human lymphoid cells were shown to possess high affinity cell surface receptors for low density lipoprotein (LDL), the major cholesterol-carrying protein in human plasma. Binding of LDL to these receptors was followed by internalization of the lipoprotein and hydrolysis of its protein and cholesteryl ester components. Cultured lymphocytes from a patient with the homozygous form of familial hypercholesterolemia lacked cell surface LDL receptors and therefore failed to take up and degrade the lipoprotein with high affinity. Cultured human lymphocytes should prove useful for further studies of: (a) the relation between cholesterol metabolism and cellular function and (b) the mechanism by which LDL binding at the cell surface leads to internalization of the lipoprotein.
Authors:
Y K Ho; M S Brown; H J Kayden; J L Goldstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  144     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-10-29     Completed Date:  1976-10-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  444-55     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Apoproteins / metabolism
Binding Sites
Biological Transport
Cell Line
Cholesterol / metabolism
Concanavalin A / metabolism
Homozygote
Humans
Hydrolysis
Hypercholesterolemia / genetics,  metabolism*
Lipoproteins, HDL / metabolism
Lipoproteins, LDL / metabolism*
Lymphocytes / metabolism*
Receptors, Drug*
Chemical
Reg. No./Substance:
0/Apoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Receptors, Drug; 11028-71-0/Concanavalin A; 57-88-5/Cholesterol
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 8 Year: 1976
Volume: 144 Issue: 2
First Page: 444 Last Page: 455
ID: 2190383
Publisher Id: 76263430
PubMed Id: 182894

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia


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